Karen A. Fisk, 62, of Pearl, passed away on July 31, 2021 at Kings Daughter Medical Center in Brookhaven, Mississippi. A native of Jackson, Mississippi Karen was born on April 15, 1959, to her late parents, Rev. John W. Fisk, Sr., and Bobbie Gardner Fisk. She worked as a Dietician before becoming a Registered Nurse. She was a graduate of Mississippi College and worked as a travel nurse before being employed as an RN with the University of Mississippi Medical Center, where she has worked for the past 15 years. Karen is survived by her sister, Pam Derrow, and her husband, Rob, of Overland Park, Kansas; brother, Dr. John W. Fisk, Jr., and his wife, Karen Hardy Fisk, of Novato, California; nieces, Jennifer J. Derrow, Lara A. Derrow and Lacey E. Derrow; and nephews, Stephen L. Fisk and Robert W. Derrow along with his wife Carlee. Visitation will be held Monday, August 2, 2021, 5:00 pm - 7:00 pm at Natchez Trace Funeral Home in Madison, Mississippi. A graveside service will be held on Tuesday, August 3, 2021, 10:00 am at the Terry Cemetery, Terry, Mississippi. In lieu of flowers, memorials may be made to Gideon's International: https://www.gideons.org/donate